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In mice subjected to a methionine-choline-deficient diet, vitamin E antioxidant therapy restored GSH levels (Phung et al

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The generation of nitric oxide (NO) from inducible nitric oxide synthase (iNOS), which is secreted by macrophages, and its metabolite peroxynitrite will induce mitochondrial dysfunction under the stimulus of excessive ROS ( Figure 2f ) (134)