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The study found that pre-operative fasting for 3 days reduced infarct volume in rats with severe focal stroke, and the neuroprotection was associated with the regulation of innate immunity: elevated circulating neutrophil chemokine ligand 1 before ischemia and reduced pro-inflammatory markers (TNF- and its receptor, as well as downstream intercellular adhesion molecule-1) in the striatum after reperfusion

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The review further discusses the synergistic effects of these compounds when combined with conventional treatments like radiotherapy and chemotherapy, highlighting their role in enhancing efficacy and mitigating side effects

doi: 10.3390/ijms20194924 457 BuechlerCKrautbauerSEisingerK