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Fujimoto T, Kogo H, Ishiguro K, Tauchi K, Nomura R

Taken together, our findings indicate that the LOTUS domain proteins EGGD-1 and EGGD-2 limit RNAi inheritance

This means that the more estrogens are conjugated by sulphation or glucuronidation, the lower the conversion into estrogen quinones, which can subsequently be converted into glutathione conjugates or lead to the formation of DNA adducts