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For example, a compelling animal or in vitro model might demonstrate a pathologic process analogous to human disease when a vaccine antigen is administered under conditions similar to human use

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Stengel and Tach, 2014b)

In multiple neurodegenerative disease models, lipid-based nanoparticles, polymeric systems, vesicular carriers, and dendritic platforms consistently enhance brain accumulation and neuroprotective efficacy when rationally designed