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Ballesteros, J

4.3 Renal fibrosis and extracellular matrix remodeling Renal fibrosis is the common pathological endpoint of various chronic kidney diseases (CKD) and is characterized by fibroblast activation, epithelial-to-mesenchymal transition (EMT), and abnormal accumulation of the extracellular matrix (ECM), ultimately leading to nephron destruction and loss of function ( -SMA and collagen I, promoting interstitial remodeling

Objective evaluations were scored according to spot ultraviolet (UV), spot polarization, skin tone, and efficacy on the medial side of the face photographed using a Janus Facial Analysis System (PIE Co., Ltd, Suwon-si, Gyeonggi-do, Korea), which uses a pigment technology system that assesses the pigment distribution objectively according to three light exposure typesnamely, normal, polarizing, and UV light