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For instance, the seleno-glutathione peroxidase mimic ebselen (PZ51) protected the endothelium and vasculature of stroke-prone spontaneously-hypertensive rats (SHRsp) during chronic hypertension (37), indicating an important role for this enzyme in the maintenance of vascular homeostasis (37)

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Kumar SK, Rajkumar V, Kyle RA, van Duin M, Sonneveld P, Mateos M-V, et al

Variability in natural product extraction protocols (e.g., solvent type, purification steps) leads to inconsistent bioactive metabolite profiles, making it difficult to attribute observed effects to specific AMPK modulators

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