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The diverse types of nitrosamines, their metabolic pathways, and their accumulation in the bladder position them as critical targets for research and prevention strategies related to this malignancy

661 These molecules function by inhibiting the PI3K/Akt signaling pathway and activating mitochondrial apoptotic pathways

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Rigorous clinical investigations are warranted to delineate the regulatory networks influenced by probiotics in colorectal cancer, elucidate their sequential mechanisms of action, and facilitate their integration as adjuvant therapeutic modalities for colorectal cancer prevention and management (302)

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