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For example, in response to hyperglycemia, histone methyltransferase Setd7 protein accumulates in the nucleus of ECs, which promotes Il - 8 , Icam1 , and Cxcl2 expression in an H3K4me1-dependent manner, and inhibits Hmox1 expression in an H3K4me1-independent fashion to regulate hyperglycemic memory [115]