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Analysis of secreted embryonic alkaline phosphatase activity in HEK293T cells demonstrated that N 4 -acetylation significantly affects the NF-B pathway and alleviates PKR activation, although it does not reduce TLR3 activation compared to cytidine [190]

ALA has anti-oxidant properties and protects against oxidative stress, which may be beneficial given the potential role of mitochondrial dysfunction and neuroinflammation in the pathogenesis of FM [72, 73]

458 ViallardJFBlancoPAndrMEtienneGLifermanFNeauDet al

doi:10.1542/peds.2012-2465 [12] R V, Dhiman P, Kollipaka R, P S, V H

This can lead to a B12 deficiency over time