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Mitochondrial dysfunction or increased ROS levels

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In addition, by integrating WES, WGS, RNA sequencing (RNA-seq), miRNA, and DNA methylation analysis, along with high-resolution mass spectrometry proteomics data, researchers successfully classified Lung Adenocarcinoma (LUAD) into four subtypes with different clinical and molecular characteristics, discovering unique mutation features associated with specific populations (Heo et al., 2021)

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There are cardiologists who used to do open heart surgeries making millions of dollars a year, and by their mid-thirties or forties, they gave it up to help people before they require surgery