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Quinlan PT, Lane J, Moore KL, Aspen J, Rycroft JA, OBrien DC (2000) The acute physiological and mood effects of tea and coffee

In this context, the intranasal route has emerged as a promising solution for delivering treatments directly from the nose to the brain through the olfactory and trigeminal nerve pathways and thus, bypassing the BBB

As a result, muscles receive signals without proper regulation, so increased muscle tone and involuntary contractions after spinal cord injury occur not because of the muscles themselves, but because of a change in the way the nervous system controls them

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