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Neurometabolites were quantified with LCModel [48], with prior reported chemical shifts and coupling constants [49, 50] as a basis for the model spectra of aspartate (Asp), ascorbate/vitamin C (Asc), glycerophosphocholine (GPC), phosphocholine (PC), creatine (Cr), phosphocreatine (PCr), -amino-butyric acid (GABA), glucose (Glc), glutamine (Gln), glutamate (Glu), glutathione (GSH), myo-inositol (myo-Ins), N-acetylaspartate (NAA), N-acetylaspartylglutamate (NAAG), phosphoethanolamine (PE), scyllo-inositol (scyllo-Ins) and taurine (Tau) were generated based on previously reported chemical shifts and coupling constants.by using GAMMA/PyGAMMA simulation library of VESPA for applying the density matrix formalism (Versatile Simulation, Pulses and Analysis 9)

Persistent disruption of daily biological rhythms can independently promote hepatic cancer in human liver cells