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In a placebo-controlled RCT, Sharafkhan et al

The incidence of hypertension in patients with PCOS can be as high as 13.1%, which is 1.75 times higher than that in non-PCOS patients (Glintborg et al., 2018)

151,152 A prospective cohort study in 40 women with PCOS found that melatonin supplementation reduced male hormone levels, normalized other reproductive hormones, and improved menstrual regularity