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Clinical validation employed TCGA Firehose Legacy datasets and multiplex immunofluorescence (mIF) on prostatectomy samples from the ProMPT cohort to correlate IGF-axis activity (serum IGF-1, tumor IGF1/IGFBP5 expression) with PD-L1 expression and immune infiltration

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Rheumatoid Arthritis (RA): Rheumatoid arthritis symptoms can temporarily improve during pregnancy (due to high estrogen), but worsen again after menopause

59 Although multiple clinical trials have indicated high dietary soy isoflavone intake decreases the overall risk of breast cancer, 60 the possible protective effect of isoflavone supplements on breast cancer risk may be limited to estrogen receptor-expressing (ER+) tumors and women in perimenopause or early postmenopasue

Treatment with maggot extract components resulted in a marked increase in the splenic Treg frequency and Foxp3 expression levels, concomitant with reduced expression of the GATA3 and RORt transcription factors