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4.5.2 ER stress-induced CHAC1 expression and ferroptosis ER stress-induced CHAC1 expression contributes to ferroptosis by disrupting GSH homeostasis, which is crucial for cellular antioxidant defense

As an example, an international study consisting of data from 2.5 million patients from Asia, Australia, Europe, and North America found that with each additional alcoholic drink consumed daily, the risk of pancreatic cancer increased by 3 percent compared to not consuming alcohol daily or at all (282)Naudin S, et al