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[DOI] [PMC free article] [PubMed] [Google Scholar] 109.Andrich D.E., Melbouci L., Ou Y., Auclair N., Mercier J., Grenier J.-C., Lira F.S., Barreiro L.B., Danialou G., Comtois A.-S., et al

It encompasses the structural and functional aspects of the cellular surroundings, but also the presence of metabolites such as glucose, amino acids and lipids within the TME, as well as environmental factors such as hypoxia and acidity (81)

GLOW is the simpler version focused on skin and tissue-quality remodeling

Models of leptomeningeal metastasis from breast, liver, and lung cancers similarly show upregulation of CHAC1, indicative of cystine deprivation and GSH depletion 49