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Interestingly, the thiol antioxidant NAC, which is a precursor for GSH biosynthesis and GSH per se could restore T-cell functions in the presence of SFN

In Jerne's own words the discovery 'deeply impressed' him and was key to his 'speculation about the mechanism of antibody formation.' Importantly it galvanised his realisation that antibodies 'are already there' without prior contact with an antigen (Sderqvist, 2003)

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As the worlds populations are rapidly heading toward an aging society and human life spans are increasing, this problem will certainly be of greater magnitude in the foreseeable future

6.4 Crosstalk with gut microbiota and adipokine networks The gut-endocrine-ovarian axis has emerged as a critical interface linking metabolic, inflammatory, and reproductive disturbances in PCOS