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Interestingly, GFR remained increased even 14 days after cessation of rhIGF-1 therapy compared to placebo-treated controls, suggesting that rhIGF-1 resulted in renal hypertrophy, since the hemodynamic effects should have worn off within 14 days of cessation

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Second, the CD cavity can be functionalized with targeting ligands, such as antibodies or peptides, to improve targeting efficiency and reduce off-target effects 59

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