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thus, a catalytic cycle is formed

MASLD is particularly prevalent among individuals with metabolic dysfunction, with a reported prevalence of up to 68% among patients with type 2 diabetes mellitus (T2DM), while obese individuals have more than a threefold elevated risk of developing this condition [3, 4]

The researchers discovered that glutamine metabolism is impaired in the obese state, leading to increased chromatin O-GlcNAcylation and activation of genes in proinflammatory pathways

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Environmental factors, gut health, immune function, and other variables also play roles