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Were tethered to our electronics, anxious and overworked and not sleeping enough

Charejoo (2023)

We discuss the molecular mechanisms underpinning hypoxia-driven metabolic adaptations, highlight their implications for tumor progression and therapy resistance, and explore emerging strategies aimed at disrupting these processes to improve cancer treatment outcomes

PUD results from an imbalance between the protective (e.g., mucus, bicarbonate, prostaglandins, antioxidant system and cell proliferation) and destructive (e.g., gastric acid, pepsin, Helicobacter pylori , stress, nonsteroidal anti-inflammatory drugs (NSAIDs) and alcohol) factors (Laine et al