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10.1016/j.ymthe.2021.03.002 241 TsoiK

This is hyperplasia, not just hypertrophy

In aged rodents, spermidine (SPD) or spermine (SPM) increased median and maximal lifespan by 1018% and reduced mortality by up to 35%, while maintaining cardiac, metabolic, hepatic, and neuronal functions [103,104]

doi: 10.1007/s00125-020-05333-y 65 MishraMKowluruRA

Both, the alpha-class related gst-32 and the GPX are implicated in the oxidative stress response by way of their GSH-dependent reduction of inorganic and organic peroxides or by their ability to eliminate secondary products of lipid peroxidation