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Parkinsons disease Parkinson's disease (PD) is the second most common neurodegenerative disorder, characterized by motor symptoms such as bradykinesia, rigidity, rest tremor, and postural instability

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Like RO4929097, several other compounds that target important cellular signaling pathwayssuch as Notch, Wnt/-catenin, JAK/STAT, NF-B, Hedgehog, PI3K/Akt/mTOR, and TGF/SMADhave been shown to target CSCs in various cancer types [48,49,50]