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However, adverse alterations in mtDNA copy number or integrity are closely associated with the development of metabolic diseases, such as diabetes ( PGC-1 and TFAM expression and eventually inhibits mitochondrial biogenesis ( Additionally, it is important to note that AR may play detrimental roles in multiple mitochondrial processes through localization to mitochondria in prostate tissues and cell lines

with age, causing low acetylcholine levels which in turn are thought to contribute to the impairment of brain function that is associated with aging

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