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Accessed at ncbi.nlm.nih.gov/books/NBK548087 on December 11, 2023

However, during high-fat diet (HFD) feeding, obesity and insulin resistance, the accumulation of medium-chain and long-chain acylcarnitines due to incomplete -oxidation may negatively regulate the expression of nuclear-encoded mitochondrial genes, further reducing mitochondrial number and function and creating a vicious metabolic cycle [33]

Saneian & al

The existence of the remnant receptor pathway was suggested by the fact that patients with homozygous FH, who completely lack LDLR function, have severely elevated levels of LDL-C but normal blood levels of triglycerides

Recent studies have suggested that glycemic variability may serve as an independent risk factor for DN, affecting both peripheral and autonomic nerve functions (Zhang X