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doi: 10.1034/j.1399-3054.2002.1140201.x 8 Clemente-MorenoM

Temporal precision in HAGSH scaffolds arises from ROS-responsive glutathione release , wherein oxidative stress at the wound site induces cleavage of redox-labile linkers such as disulfide, thioketal, or aryl boronate moieties [18]

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it permits to elucidate the mechanisms of penetration of these systems in relevant skin models and to uncover the cellular uptake of drugs

This resistance is mediated by different causes and mechanisms, (that are resumed in Table 1 and excellently summarized in different review articles [78].One of the most obvious and intriguing mechanisms of resistance involves alteration in CD38 expression, a crucial factor in both primary and acquired resistance to anti-CD38 therapies