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Notably, animal models have demonstrated that transferring dysbiotic microbiota from CFS/ME patients to germ-free mice can induce fatigue-like behaviors, supporting a causal role for the microbiome in disease pathogenesis ( 3.5.4 Gut microbiota-based therapeutic interventions 3.5.4.1 Probiotics Given these findings, probiotic supplementation, particularly with strains of Lactobacillus and Bifidobacterium , has shown potential to restore microbial balance, enhance SCFA production, and reduce inflammation in CFS/ME patients (Skjevling et al., 2024)

10.1126/sciadv.adr8243 200 HuangH.XuH.LuoQ.HeJ.LiM.ChenH.et al

HER2 in metastatic colorectal cancer: pathology, somatic alterations, and perspectives for novel therapeutic schemes

Conflict of interest The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest

Adesanya AW, Morales MA, Walsh DB, Lavine LC, Lavine MD, Zhu F