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Because IL-1 immediately responds to a wide diversity of pro-inflammatory insults and affects the function of many targets, it is essential to limit the potentially harmful aspects of inflammation by negatively regulating IL-1 expression [92]

doi: 10.3746/pnf.2017.22.1.1

Combination treatments Combination therapies are often used in patients with NP who have either failed to have a response, or only had a partial response to monotherapy [16]