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The repair cycle starts with the monomerization of phosphorylated dimeric PSII complex in grana stacks and is continued by dephosphorylation of D1, D2 core proteins and CP43 most probably while passing through only loosely stacked non-appressed stroma-exposed thylakoids

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Similarly, ICV pretreatment or peripheral post-treatment with the DEETGE-Cal-Tat peptide was also able to decrease Keap1-Nrf2 interaction in the rat hippocampal CA1 region after global cerebral ischemia (GCI) and, as a consequence, to induce Nrf2 target genes and a powerful neuroprotection of hippocampal-dependent cognitive function after GCI [302]

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Late diagnosis is increasingly common, particularly for adults who grew up when awareness of these conditions was more limited