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Footnotes Appendix A Supplementary data to this article can be found online at Contributor Information Chunfeng Yao, Email: [email protected]

This name was coined after the adrenal glands where it was first isolated in 1901 by the Japanese chemist Jokichi Takamine

Epsin, a member of the ubiquitin-binding endocytosis adaptor protein family, engages with the linear ubiquitin chain assembly complex (LUBAC) to facilitate the linear ubiquitination of the NF-B essential modulator (NEMO)