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G6PD Deficiency: This rare genetic enzyme deficiency can react poorly to high dose Vitamin C

Kang L, Jiang D, Ehlerding E, Barnhart T, Ferreira C, Wang R, et al

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Serious bacterial infections requiring hospitalization or intravenous antibiotics may occur and appear to be more prevalent during the first 6 to 12 months of TNF inhibitor therapy, likely because patients at greatest risk may develop this complication early, then discontinue therapy