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Insulin activates the rat sterol-regulatory-element-binding protein 1c (SREBP-1c) promoter through the combinatorial actions of SREBP, LXR, Sp-1 and NF-Y cis -acting elements

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The intrinsic factor then binds with B12, facilitating the uptake of B12 in the small intestines.[ref] Without intrinsic factor, you cant absorb B12 from animal proteins