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Mutations in coenzyme Q10 biosynthetic genes

Discussion Glioblastoma is a universally fatal type of cancer characterized by molecular diversity and intratumoral heterogeneity 42

& Swindells, M

In line with the increased caspase 3/7 activity in IMR-32 and CLB-GA, mRNA expression of the pro-apoptotic genes BAX , PUMA and NOXA was upregulated following combination treatment while increased gene expression of CDKN1A and RRM2B indicates p53 pathway activation (Fig