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This damage leads to the oxidation of LDL within the vessel walls, initiating an inflammatory response and the formation of foam cells

The importance of this antioxidant pathway is illustrated in Nrf2 knockout mice in which lung neutrophil inflammation and pulmonary emphysema were evident as early as 8 weeks after cigarette smoke exposure, whereas wild-type mice showed no lung changes at 16 weeks

WS balances the Th2-Th1 immune responses in mice by upregulating Th1 immune responses along with an increase in CD4 and CD8 T cells [87]

Int Immunopharmacol 2024;132:112013

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