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In this scenario, drug class may matter for both biology and tolerability: signals for metformin vary by metabolic phenotype and may reflect improved glycemic control and weight rather than a direct anticancer effect [115, 118, 119]

Exposure of cultured human hepatocytes to alcohol increased the expression of CYP-2E1 and CYP-3A3/4 up to 6-fold, but the effect appeared to be individually variable [47]