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After 24 hours of postovulatory aging: Intracellular ROS levels decrease Mitochondrial membrane potential remains stable mtDNA copy number stays consistent Cortical granule abnormalities and spindle defects are reduced DNA damage (H2AX) and early apoptosis markers decline Early apoptosis decreases Fragmentation rates fall during parthenogenetic activation These results highlight Epithalons role in combating oxidative stress and mitochondrial decline in reproductive cells

Using genetic and pharmacological approaches to stimulate or antagonize the TGF- pathway in human glioma-initiating cells (GIC), we observed that TGF- exerts an inhibitory effect on c-MET phosphorylation

doi: 10.1186/s40035-025-00515-3 210 QianJ.GuoY.XuY.WangX.ChenJ.WuX