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They begin at the cellular level due to oxidative stress, excess melanin production, inflammation, and reduced collagen activity

Proc Natl Acad Sci USA 89:71897193 Hanuska A, Sznsi G, Albert M, Koles L, Varga A, Szabo A, Matyus P, Harsing LG (2016) Some operational characteristics of glycine release in rat retina: the role of reverse mode operation of glycine transporter type-1 (GlyT-1) in ischemic conditions