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Concurrently, the AMPK pathway, studied for its potential in energy balance and metabolism regulation, may be indirectly influenced by IGF-1 analogs

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However, the mechanistic details still need to be investigated

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111-114 However, two placebo-controlled trials found 1,500 mg curcumin and other curcuminoids per day in addition to lifestyle changes for 12 weeks did not lead to statistically significant improvements in NAFLD or markers of inflammation or cardiovascular risk when compared with lifestyle changes alone