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Schneweis et al

Although the exact mechanism of how coffee enemas cause proctocolitis is not known, it is suspected that the proctocolitis is caused by the chemicals in coffee enemas, as coffee is a complex mixture of chemical compounds that contain more than just caffeine

Int J Mol Sci (2020) 21(17):6451

Moreover, aryl hydrocarbon receptor is an immune regulatory transcription factor (Mariuzzi et al., 2016)

CD8 + cells recognize the encephalitogenic epitope myelin OL protein 35 50 (MOG 35 50 ) and induce demyelination through the secretion of granzyme B, lymphotoxin, and IFN ( HGF and Stem Cell Therapies for Neuroregeneration Neural stem cells (NSCs) are the stem cells of the nervous system, to which they give birth during development