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Acute Phase Reaction In patients given Reclast at randomization and placebo at Month 12, Reclast was associated with signs and symptoms of an acute phase reaction: myalgia (20.4%), fever (19.3%), chills (18.2%), pain (13.8%), headache (13.3%), fatigue (8.3%), arthralgia (6.1%), pain in extremity (3.9%), influenza-like illness (3.3%), and back pain (1.7%), which occurred within the first 3 days following the dose of Reclast

Morita W, Snelling SJB, Wheway K, Watkins B, Appleton L, Murphy RJ, Carr AJ, Dakin SG

After treatment, 100 L of CCK-8 working solution was added to each well of the 96-well plate, followed by incubation at 37 C and 5% CO 2 in the dark for 1 h