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Warm-sensitive neurons in the preoptic area are a key sensor and regulator of thermal homeostasis [60, 61] that project to distinct effector regions in the brain to regulate brown adipose tissue activity and skin vasodilation [26, 58]

Ce phnomne peut tre aggrav par certains facteurs tels que le vieillissement, les dsquilibres hormonaux ou une exposition solaire excessive sans protection adquate

SETDB1 deficiency clearly promoted the acquisition of the TGF--induced mesenchymal phenotype but reduced the expression of E-cadherin in human alveolar epithelial cells by catalyzing the deposition of H3K9me3 on Snai1 , which inhibited the protein expression of Snai1, the main transcription factor that initiates the epithelial-mesenchymal transition (EMT)

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26 Clinicians must not overlook the PSPS presentation, for which do no harm is the most important consideration