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One example entering trials is ex vivo cytokine-treated monocytes essentially training a patients monocytes to be more anti-inflammatory and better at phagocytosis by culturing them with IL-4/IL-10, then infusing them back (this approach is being tested in sepsis under the name GM-CSF tuned monocytes)

Harjunmaa U, Doyle R, Jrnstedt J, Kamiza S, Jorgensen J, Stewart C, Shaw L, Hallamaa L, Ashorn U, Klein N, Dewey K, Maleta K, Ashorn P (2018) Periapical infection may affect birth outcomes via systemic inflammation

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Her symptoms had begun approximately one year prior to coming to Ronald Davis, M.D