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Modulation of ATR-mediated DNA damage checkpoint response by cryptochrome 1

Patients were randomized to receive venetoclax (orally initiated on Day 22 of Cycle 1 [28-day cycles] with a 5-week escalation [20 mg, 50 mg, 100 mg, 200 mg, then 400 mg daily for 1 week], continuing at 400 mg daily until completion of cycle 12