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10.1038/s41401-021-00781-7 48 LiM.ZhaoX.XieJ.TongX.ShanJ.ShiM.et al (2022)

[30] In December, 2020, Sinclair's group published that three Yamanaka transcription factors, Oct4, Sox2, and Klf4, when delivered together in a virus, could safely reverse the age of human and mouse cells, and restore the vision of old mice and mice with glaucoma

In prklinischen Tiermodellen und einer frhen Phase-I-Studie am Menschen wurde T4 berwiegend gut vertragen

However, overdoing it can lead to potential side effects and skin issues

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