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256 However, in various clinical trials investigating its antitumor efficacy, siltuximab monotherapy demonstrated limited clinical activity, prompting a strategic shift toward exploring its role in combination therapies

They provide no evidence or arguments for these beliefs

Plasma was separated from the blood by centrifugation at 860g for 20 min and stored at -80C

doi: 10.1093/hmg/ddu328 13 SmithGDEbrahimS

Specifically, the drug resistance mechanisms of HGSOC are primarily manifested in tumor cell heterogeneity, which leads to significant differences in drug response among various cell subpopulations