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Ellis et al8 reported a case of melanoma (Breslow depth of 1mm) in a 23-year-old patient who consulted for an increase in size of a pigmented lesion on his leg after use of Melanotan I

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CAS 189691-06-3) is a synthetic cyclic heptapeptide analog of the endogenous hormone -melanocyte-stimulating hormone (-MSH) that functions as an agonist of the melanocortin receptor system , with preferential activity at the melanocortin-4 receptor (MC4R) believed to mediate its central nervous system effects on sexual response