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The lead analogue, RgIA-5524, incorporating a methylene thioacetal in loop II, demonstrated potent inhibition of human 910 nAChRs (IC 50 = 0.9 nM), exceptional selectivity across a wide range of pain-associated ion channels and receptors, and significantly improved serum stability by preventing disulfide scrambling

Suggested Use Take 1 capsule daily, preferably on an empty stomach

By restoring balanced DHEA levels, Bio DHEA promotes healthy metabolism, supports reproductive health in both men and women, boosts libido, and helps maintain optimal energy levels

10.1016/j.acthis.2017.04.002 76 ItoS.NakashimaM.IshikiriyamaT.NakashimaH.YamagataA.ImakiireT.et al (2022)

By combining them into one daily-use capsule, the formula offers a convenient option for individuals who want to address multiple wellness considerations without juggling multiple products