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CagriSema produced 22.7% more than either component and more than simply adding the two together would suggest

Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome

When administered directly into the cerebrospinal fluid of mice, it showed dose-dependent pain-relieving effects that were blocked by naloxone, confirming involvement of opioid pathways

Conclusions In summary, Schwann-like cells converted from GMSCs retained potent immunomodulatory functions to promote pro-regenerative (M2) macrophage polarization and suppress pro-inflammatory (M1) macrophage activation

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