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Oxidative stress occurs when the production of ROS exceeds the capacity of cellular antioxidant systems to control redox balance and prevent oxidative damage through mechanisms such as ROS scavenging, metal ion chelation, modulation of redox signaling pathways, and activation of endogenous antioxidant defenses (Liu et al., 2020)

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Additionally, berberine reduces ROS generation and cellular apoptosis while inhibiting NF-B activation and adhesion molecule expression, thereby preventing monocyte attachment to endothelial cells

NMN and NR as NAD precursors: Which is better