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Frataxin deficiency is associated with imbalances in iron-sulfur containing proteins, mitochondrial respiratory chain dysfunction and lower ATP production, and accumulation of iron in the mitochondria, which increases oxidative stress and oxidative damage to macromolecules of the respiratory chain (77)

pH-sensitive molybdenum (Mo)-based polyoxometalate nanoclusters have therapeutic efficacy in inflammatory bowel disease by counteracting ferroptosis

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Furthermore, treatments targeting chondrocyte mitochondria require additional mitochondrial targeting design, often achieved by conjugating drugs to lipophilic cations or mitochondria-penetrating peptides (125)