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Schuster SJ, Bishop MR, Tam CS, Waller EK, Borchmann P, McGuirk JP, et al

Amino acid metabolism plays a significant role in mediating the effect of the Hippo pathway on ferroptosis

NAD + has an essential role as a source of ADP-ribose for three main classes of enzymes, each releasing nicotinamide as a byproduct: 1) mono- and poly-ADP-ribosyltransferases (ARTs, formerly PARPs) utilize ADP-ribose to modify proteins post-translationally and get activated during DNA repair processes 8